When to use the autoresponder feature is entirely up to you. Often, businesses use autoresponders to let others know when they are out of the office, to acknowledge receipt of emails, and to confirm and thank customers for orders they may have placed.
(1) You may create a autoresponder email via login into your Direct admin account and choose Auotoresponders in the Email Management section
(2) Select Create New Autoresponders
(a) Fill in the username for the email account
(b) Fill in the message which you want to autorespond when your email account received a email in the Responder Message column.